State Summer Symposium Supports Biomedical Research

The 22nd Summer Research Symposium of the West Virginia IDeA Networks of Biomedical Research Excellence – or INBRE – was held in Morgantown last week. Dozens of undergraduate researchers packed into a hotel conference hall to show off their summer’s work.  

An annual, statewide symposium is enhancing biomedical research in West Virginia’s colleges and universities. 

The 22nd Summer Research Symposium of the West Virginia IDeA Networks of Biomedical Research Excellence – or INBRE – was held in Morgantown last week. Dozens of undergraduate researchers packed into a hotel conference hall to show off their summer’s work.  

Gary Rankin is the lead investigator for the program. He said the symposium is a highlight of the year because it brings scientists together to support the next generation of researchers.

“The quality of the presentations this year has been really good,” Rankin said. “They range from looking at diabetes, to cancer, to environmental pollution, to all sorts of health effects, and particularly those that are appropriate to West Virginians.”

West Virginia INBRE is funded by the National Institute of General Medical Sciences.  Through a statewide research consortium it has promoted biomedical research in the state  for more than 20 years. The meeting is the culmination of a nine week summer research program where undergraduates from across the state present their work and discuss it with faculty. 

Two such undergraduate researchers were Doris Agyemang of Glenmont State University and Katie Long of Fairmont State University. They partnered up while in the program to look at genes and gene therapies related to type two diabetes.

“Basically, all the methods used for this research were from what we learned during the boot camp for the month,” Long said. “We also got to work directly with the people who invented some of the newer stuff that we were using that hasn’t really been used a lot in the science field yet.”

Agyemang said they haven’t broken new ground with their work, but it’s still encouraging to contribute their research, and further conversations with other scientists and faculty working on the issue.

“Giving them another way or view on it is also interesting to us and hopefully, we get more chances like this in the near future,” she said. 

Travis Salisbury is an associate professor at Marshall University whose own research focuses on gene expression. He said the symposium allows undergraduates – who don’t have as many opportunities to conduct their own hands-on research – a unique opportunity to find the spark that will set them on their own career paths.

“I think that’s what it is, it’s just exposing them to research to see if they’re interested in doing research further on, because that’s really how most of us got started, is just a science project,” Salisbury said. 

Salisbury also said the symposium is an opportunity for working scientists like him to rekindle their passion for research and be assured the future of their work will be in good hands.

Negotiating Higher Ground And Emerging Appalachian Voices This West Virginia Morning

On this West Virginia Morning, differences in opinion on how to build high ground communities in Eastern Kentucky and a conversation with the editor of a new collection of essays.

On this West Virginia Morning, the increases the risk of flooding in eastern Kentucky has spurred the state to build high ground communities to help residents. But one small mountain town has their own plan for high ground homes.

Also, Inside Appalachia’s Mason Adams speaks with Zane McNeill, the co-editor of a new collection of essays exploring the intersection of queer Appalachian life and the environment.

And, a short look at annual West Virginia symposium enhancing biomedical research in the state’s colleges and universities.

West Virginia Morning is a production of West Virginia Public Broadcasting, which is solely responsible for its content.

Support for our news bureaus comes from Shepherd University.

Maria Young produced this episode.

Listen to West Virginia Morning weekdays at 7:43 a.m. on WVPB Radio or subscribe to the podcast and never miss an episode. #WVMorning

Marshall, WVU Receive Funding To Support Student Success

The National Science Foundation has awarded West Virginia’s two largest universities funds to improve student success.

The National Science Foundation has awarded West Virginia’s two largest universities $656,814 for research initiatives to improve student success.

Marshall University will receive $352,310 for a ten-week interactive research program to engage STEM students with career workshops and hands-on learning opportunities.

The rest of the funds -$304,504 – will support research at West Virginia University to assess obstacles faced by socioeconomically disadvantaged graduate students and the effect that these disadvantages have on student retention.

The National Science Foundation was established in 1950 by Congress to promote the progress of science and according to their website, their grants account for about 25 percent of federal support to America’s colleges and universities for basic research.

Shepherd Study Treats Substance Use Disorder With Light Therapy

Researchers at Shepherd University are using light therapy to treat symptoms of substance use disorder and depression, and say they have found early signs of success.

Scientists have long recognized the impact of sunlight on vitamin intake, sleep patterns and mood.

But researchers at Shepherd University are taking things a step further with a form of light therapy known as photobiomodulation (PBM). Their goal is to use light to address symptoms of substance use disorder and depression.

The study involves placing a non-invasive helmet over a participant’s head and transmitting near-infrared light for three minutes. Participants regularly attended these sessions, receiving the treatment twice a week for eight consecutive weeks.

This helps stimulate energy production in cells, reduce inflammation and aid the healing of nerves, according to Jennifer Flora, director of the Shepherd University Wellness Center and a co-author on the study.

So far, Flora said the results have been promising. “I was like, ‘You need to run these numbers again,’ because it was so shocking,” she said.

“After eight weeks, those in the PBM treatment group reported significantly fewer cravings and less severe symptoms of depression compared to the control group,” Flora said. “The results were so compelling.”

Flora is working on the project alongside Kelly Watson Huffer, co-author and coordinator for Shepherd’s Doctor of Nursing Practice program.

The results of Flora and Watson Huffer’s study were discussed on Shepherd’s campus Monday, with a presentation on the second phase of the study.

West Virginia officials and Shepherd University staff gathered for a Monday morning presentation on photobiomodulation therapy and substance use disorder.

Photo Credit: Jack Walker/West Virginia Public Broadcasting

This will be conducted at the Berkeley Day Report Center in Martinsburg, which serves as an alternative to incarceration for individuals who have gone through legal troubles tied to substance use disorder.

The second phase of the program will continue its phase-one light therapy interventions and compare their results for a second group of participants.

Several state officials attended Monday’s event and expressed their hopes that the study could soon benefit West Virginians.

“The work that’s going on in Shepherd is a critical part of the future of how we tackle the drug epidemic,” said Attorney General Patrick Morrisey. “There [is] a need for additional approaches, creative approaches, to help really make a big difference at some of these cravings, [to] go after the science of addiction.”

“West Virginia has been sort of the most hard-hit place in the country with the opioid epidemic,” said West Virginia State Auditor J.B. McCuskey. “The work that our universities are doing locally to find non-pharmacological solutions to this [is] incredible.”

Flora said her team is currently developing a more portable version of the helmet, which could help people access PBM from the comfort of their homes.

In the meantime, she encouraged state and local officials to consider expanding access to PBM and emerging therapeutic treatments.

“As we continue our research we invite the community — health care professionals and policymakers — to consider the potential of innovative therapies like photobiomodulation to make a real difference,” Flora said.

Shepherd University Secures 3 Years Of Funding For Student Research

A new $160,000 grant from the West Virginia Higher Education Policy Commission will fund three years of a student research program at Shepherd University in West Virginia’s Eastern Panhandle.

A new grant from the West Virginia Higher Education Policy Commission (HEPC) is furthering student research in West Virginia’s Eastern Panhandle.

The Shepherd Opportunity to Attract Research Students (SOARS) program pairs students with university faculty for summer research projects, providing them a stipend for their work.

A new HEPC grant of more than $160,000 will allow the program to continue for the next three years.

Participants in the program select a scientific research project they want to work on alongside a professor, receiving mentorship over the course of the summer.

At summer’s end, students have the opportunity to present their research. Later, they complete a capstone project from their findings.

This marks the fifth cycle of the SOARS program, which welcomes 30 students in each round of the grant.

“Students who are paid on the SOARS grant in the summer have extra hours and bits and pieces that they can do,” said Robert Warburton, dean of Shepherd’s College of Science, Technology, Engineering, Mathematics and Nursing, in a Monday press release.

“That means they get extra experience, and the faculty advisor gets assistants working in the lab, which is also important because the faculty must be able to do research because of their professional development requirements,” he said. “It’s a win on both sides.”

Virginia Tech Study Explores Lack Of Water Access In Appalachian Communities

It’s an old story in Appalachia: failing water systems leaving people afraid to drink from their taps. Now, Virginia Tech researchers are putting numbers behind the stories with a study of water inequality in McDowell County, West Virginia.

This conversation originally aired in the Sept. 3, 2023 episode of Inside Appalachia.

It’s an old story in Appalachia: failing water systems leaving people afraid to drink from their taps.

Now, Virginia Tech researchers are putting numbers behind the stories with a study of water inequality in McDowell County, West Virginia. Leigh-Anne Krometis is a professor of biological systems engineering at Virginia Tech, and she was part of the team that conducted the study.

Inside Appalachia Host Mason Adams reached out to learn more.

This interview has been edited for length and clarity.

Adams: We’re talking because of a study that you and your team did in McDowell County, West Virginia. Tell us about what the study was and what y’all were looking for.

Krometis: I have been studying roadside springs for a long time. If you drive around Appalachia, I’m sure you’ve noticed people with their jugs collecting water at roadside springs. Several years ago, I started researching the water quality of those springs and why people value them, and then that led me really to look at people’s home water quality. Because when you see people collecting water, you wonder, “Well, do they have water in their homes?” My original hypothesis was, “Oh, well, these people don’t have water in their homes. And that’s why they’re choosing to go to the springs.”

In reality, the majority of the people that we have gone to their homes and interviewed and taken home water samples, they have water in their homes, they can turn on the tap and water comes out. But it’s not water they trust, or it’s not water that meets federal guidelines.

Adams: I can’t think of the number of times I’ve been at someone’s house and asked for a cup of water, and they’d tell me to drink bottled water instead.

Krometis: A colleague of mine said, “You’re gonna find out that everyone’s using bottled water anyway.” And that is really the second phase of this study, is we’re looking at the health and economic implications of having to rely on bottled water, because you have water in your home, but you can’t use it. We all know that there are food deserts. McDowell County is the only place I think in America where a Walmart failed. You have to drive 30-45 minutes just to go somewhere to buy your bottled water. It’s an added cost. Bottled water is 2,000 times the cost of what you get out of the tap. And so what does all that mean, to us, especially for people who don’t have huge household incomes?

Adams: How did you all research this question in McDowell County?

Krometis: We worked with some community groups and community contacts. We’d go to someone’s home and say, “Would you like free water quality testing?” One of the things that’s really important to me is the democratization of water science. If I collect a water sample from your home and analyze it, I give the data back to you first. That data isn’t mine, it’s yours. It’s your exposure in your home. We collect water samples, and then do a short interview about typical water-use reliance on bottled water.

Adams: What did you find in this initial round of results?

Krometis: The most obvious thing is that, especially for homes that are reliant on private water systems, people in Appalachia get pretty creative. I mean, all over the country, we see private wells and private springs, but folks here also have cisterns. They have other ways of running water into their homes. The most common contaminant we see is coliform [bacteria] and E. coli, which are bacteria that if you had them in a centralized system, it will cause a boil order, because it means that there’s actually fecal contamination. There’s a health risk. In homes that are reliant on public water, we didn’t see that because chlorine is kind of a miracle worker. We did see high levels of salt and some things that can make water taste funny in some homes.

But the more interesting thing that I found … as a water scientist, is there’s this kind of new idea called multiple water use, which is that we imagine that people in their home you turn on a tap, and that’s the water use for everything. But actually, people are making a lot more subtle choices. You might use bottled water to drink, or to use for cooking, you might go collect spring water for coffee, or for making tea. And then you use the tap water for cleaning. Or maybe you have two different wells or a rainwater cistern on your home. But this is a lot of mental work. That’s a lot. It’s not just turning on your tap for everything. You have to think about which water you’re using for what purpose. And that’s an idea that science is only just now realizing. I mean, it’s a reality people in Appalachia have known for hundreds of years. But it’s something we’re just realizing makes exposure really difficult to measure.

Adams: I’d like to go back to this question of spring water, because I know for myself, and a lot of people, they just think that water from natural springs tastes better. You’ve actually done some research. Is spring water better to drink than bottled water or tap water?

Krometis: No. The problem with “spring water” is that it’s generally not truly spring water. We have this idea that it’s groundwater, and so it’s protected from all the gross things humans are doing on the surface. But because of the underlying rocks and geology of Appalachia, it’s often not even truly groundwater. It’s surface water that has sunk under the ground and reemerged. There are lots of places where we sample that people think are springs, [but] they’re actually outfalls from historic mine sites.

Now, ironically, some of those flooded mines have pretty decent water quality, because they’re so deep, but 80 percent of the springs that I’ve sampled have E. coli in them. If you were out hiking on the Appalachian Trail or going camping, you would want to boil that water before you used it. But it looks great, right? It’s in a beautiful setting and it doesn’t taste like chlorine, but it really does not meet health guidelines.

Adams: What are some of the implications for this study and what you found?

Krometis: We’ve had some national level analyses talking about the “plumbing poverty” or water inequity, and Appalachia frequently comes up bright red, as somewhere that is challenged by this. We don’t really talk about what that means in terms of the human impacts. What is the lived experience of being in a place with plumbing poverty? That means extra time waiting at a spring, it means extra health impacts, because you’re exposed to water that doesn’t meet guidelines.

It’s just the indignity of having to spend your time juggling different ideas of what water you can serve to company versus yourself for using it to make baby formula. What I hope is that this motivates long-term investment, and also creative investment. The way that we typically create water infrastructure in America with these long water lines; it might not work for Appalachia. And people here are creative: How do we take that creativity and make sustainable healthy water systems that meet needs?

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